San Francisco Giants at San Diego Padres odds, picks and predictions – USA TODAY Sportsbook Wire

The San Francisco Giants (80-80) and San Diego Padres (88-72) play the second game of a 3-game set Tuesday at Petco Park. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Giants vs. Padres odds with MLB picks and predictions.

Season series: Padres lead 12-5

The Giants lost for just the 3rd time in their last 14 games after dropping a 7-4 decision in the series opener Monday.

San Francisco RHP Shelby Miller recorded the loss in a relief appearance, allowing 5 ER on 2 H with 1 K through 1 1/3 IP. San Diego starter RHP Joe Musgrove threw 6 scoreless innings and LF Wil Myers hit a 3-run HR to cap off a 7-run 8th inning.

The Padres remain 1 game ahead of the Philadelphia Phillies for the 2nd spot in the NL wild-card standings. Philadelphia holds the season-series tiebreaker, in case the Phillies and Padres finish with the same record.

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Giants at Padres projected starters

LHP Carlos Rodón vs. LHP Sean Manaea

Rodón (14-8, 2.88 ERA) makes his 32nd start. He has a 1.03 WHIP, 2.6 BB/9 and 12.0 K/9 through 178 IP.

Last start: Win Thursday vs. the Colorado Rockies with 6 IP, 0 ER, 2 H, 0 BB and 10 K Highest K/9 in MLB 2022 vs. the Padres: 1-2 with a 3.79 ERA (19 IP, 8 ER) in 3 starts

Manaea (7-9, 5.15 ERA) makes his 28th start and 30th appearance. He has a 1.34 WHIP, 2.9 BB/9 and 8.9 K/9 through 152 IP.

Last appearance: No-decision Thursday vs. the Los Angeles Dodgers with 4 IP, 1 ER, 2 H, 0 BB and 3 K Last start: No-decision Sept. 23 at the Rockies with 3 2/3 IP, 3 ER, 6 H, 3 BB and 2 K Has lost 4 of his last 5 decisions 2022 vs. the Giants: 0-1 with a 4.76 ERA (17 IP, 9 ER) in 3 starts

Giants at Padres odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at  11:52 a.m. ET.

Moneyline (ML): Giants +125 (bet $100 to win $125) | Padres -155 (bet $155 to win $100) Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+135) Over/Under (O/U): 7.5 (O: +105 | U: -130)

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Giants at Padres picks and predictions


Padres 4, Giants 2


BET PADRES (-155).

San Diego is still playing for seeding in the NL wild-card standings. The Padres’ offense got back on track Monday putting up 7 runs in 1 inning and should lead San Diego to another win Tuesday. Manaea has also been solid for San Diego in his last 3 appearances, allowing a combined 6 ER through 12 2/3 IP.

Run line/Against the spread

BET PADRES -1.5 (+135).

Four of the Padres’ last 5 wins have been by multiple runs. Despite how good Rodón has been this season, San Diego hasn’t seemed to struggle vs. the lefty and should be able to win convincingly Tuesday.



The Padres’ offense looked dangerous in the 8th inning Monday, but Rodón is still one of the best strikeout pitchers in MLB. There is too much conflicting data in this matchup to confidently bet the total either way.

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